Randomized trial examines cytokine response due to mechanical ventilation in acute respiratory distress syndrome, suggesting future implications for clinical outcomes.
Mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistention and recruitment/derecruitment of the lung. Whether these physiological improvements are associated with improvements in clinical end points should be determined in future studies.
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Ranieri et al. (1999) studied this question.
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