Are hypertension and diabetes mellitus determinants of multiple lacunar infarcts?
Hypertension (specifically diastolic pressure) and diabetes mellitus are strongly associated with multiple lacunar infarcts, suggesting etiologically distinct subgroups compared to single lacunes.
There may be etiologically distinct lacunar infarct subgroups, with multiple lacunes being strongly related to hypertension and diabetes mellitus. Other stroke risk factors may be more important in patients with single lacunes. Diastolic rather than systolic pressure seems to be a major determinant of multiple lacunes.
Mast et al. (Sun,) studied this question.