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August 1, 2012Journal of Pharmacy And Bioallied Sciences241 citationsOpen Access

Applications of immunohistochemistry

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JDJeyapradha DuraiyanThai Moogambigai Dental College and HospitalRGRajeshwar GovindarajanThai Moogambigai Dental College and HospitalKKKarunakaran KaliyappanJSS Dental College and Hospital

Key Points

  • To summarize the diagnostic and research applications of immunohistochemistry in identifying disease states and characterizing tissue antigen distribution.
  • Reviewed the utility of monoclonal and polyclonal antibodies for detecting tissue-specific antigen distribution in health and disease.
  • Assessed laboratory applications of immunohistochemical staining for detecting de novo or upregulated tumor antigens in clinical pathology.
  • Demonstrates that immunohistochemistry effectively maps antigen localization to distinguish normal tissue architecture from pathological disease states.
  • Highlights the critical role of immunohistochemical identification of cancer-specific biomarkers in clinical diagnostics and laboratory research.

Abstract

Immunohistochemistry (IHC) is an important application of monoclonal as well as polyclonal antibodies to determine the tissue distribution of an antigen of interest in health and disease. IHC is widely used for diagnosis of cancers; specific tumor antigens are expressed de novo or up-regulated in certain cancers. This article deals with the various applications of IHC in diagnosis of diseases, with IHC playing an important role in diagnostic and research laboratories.

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Cite This Study

Duraiyan et al. (2012) studied this question.

synapsesocial.com/papers/69da8f69615cc0c8eaa3bf7ehttps://doi.org/10.4103/0975-7406.100281
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