Do APOE and AGT gene polymorphisms synergistically increase the risk for early myocardial infarction?
The study identifies a synergistic genetic risk factor (APOE epsilon4 and AGT-TT) for early myocardial infarction, potentially mediated by elevated cholesterol.
Our data suggest a synergistic effect between the APOE and AGT polymorphisms and early MI. The increased risk could be mediated in part through higher cholesterol concentrations among individuals who are AGT-TT + APOE epsilon4 allele carriers.
Batalla et al. (Fri,) studied this question.
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