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June 27, 2023Thrombosis and Haemostasis64 citationsOpen Access

The Impact of Polypharmacy on the Effectiveness and Safety of Non-vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation

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MGMaxim GrymonprezMPMirko PetrovićTBTine L. De Backer

Structured PICO

Do NOACs improve the benefit-risk profile compared to VKAs in atrial fibrillation patients with polypharmacy?

P
Population
Patients with atrial fibrillation (AF) and polypharmacy
I
Intervention
Non-vitamin K antagonist oral anticoagulants (NOACs)
C
Comparator
Vitamin K antagonists (VKAs)
O
Outcome
Benefit-risk profile (thromboembolic, bleeding, and mortality risks)hard clinical

In atrial fibrillation patients with polypharmacy, NOACs offer a superior benefit-risk profile compared to traditional vitamin K antagonists.

Abstract

Polypharmacy was associated with increased thromboembolic, bleeding, and mortality risks in AF patients. NOACs had better benefit-risk profiles than VKAs in patients with polypharmacy.

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Cite This Study

Grymonprez et al. (2023) studied this question.

synapsesocial.com/papers/69dad49178a3e0e2886847f8https://doi.org/10.1055/s-0043-1769735
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