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January 17, 2014American Journal of PsychiatryOpen Access

There is a significant association between depression and excess mortality, although it may be overestimated due to publication bias and low study quality.

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Why the study?

Is depression associated with excess mortality in the general community versus patients with specific illnesses?

Population

General community and patients with specific illnesses

Design

Meta-analysis

Authors

PCPim CuijpersNVNicole VogelzangsJTJos W. R. Twisk

Discussion

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Overview

Depression warrants clinical attention for potential mortality risk; leaves open precise effect size due to bias and low-quality evidence.

Structured PICO

Is depression associated with excess mortality in the general community versus patients with specific illnesses?

P
Population
General community and patients with specific illnesses
I
Intervention
Depression
O
Outcome
Excess mortalityhard clinical

This meta-analysis confirms a significant association between depression and excess mortality, while highlighting that publication bias and low study quality may lead to overestimation.

Limitations

  • publication bias
  • low study quality

Cite This Study

Cuijpers et al. (2014) studied this question.

synapsesocial.com/papers/69db22a64a1e15904c837013https://doi.org/10.1176/appi.ajp.2013.13030325
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