Host gene expression analysis in the detection of bacterial and viral etiology in children hospitalized with a suspected severe infection

Key Points

• The aim is to analyze gene expression to differentiate between bacterial and viral infections in children with severe suspected infections.
• Conducted gene expression analysis in children hospitalized for suspected severe infections.
• Developed a 2-transcript signature for infection detection.
• Evaluated the accuracy of the gene expression signature in differentiating between infection types.
• The 2-transcript signature accurately distinguishes bacterial from viral infections.
• Demonstrated good diagnostic accuracy even with varying clinical presentations.