Exhaled breath condensate metabolomics reveals conserved networks and bidirectional crosstalk in asthma and CRSwNP.

Key Points

• The aim is to investigate metabolic interactions between asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) using exhaled breath condensate.
• Utilized non-invasive exhaled breath condensate (EBC) metabolomics analysis
• Analyzed conserved metabolic networks between asthma and CRSwNP
• Identified bidirectional perturbations in metabolic profiles
• Revealed conserved metabolic networks among participants with asthma and CRSwNP
• Found evidence of bidirectional crosstalk between the two conditions
• Supported the concept of a 'unified airway' hypothesis