We present a structural reinterpretation of Alzheimer’s disease within the framework of Integrated Structural Generation Theory (IGS). Rather than treating Alzheimer’s disease primarily as a biochemical disorder, we interpret it as a breakdown of persistent structural differentiation, in which the stabilization and fixation of information progressively fail over time. In IGS, cognitive processes are described as a generative chain: Difference → Fixation → Information → Meaning → Convergence → Time We propose that Alzheimer’s disease emerges as a disruption of this chain, driven by the degradation of structural stability parameters. We introduce a minimal mathematical formulation in which key structural parameters become time-dependent and decrease over time: η = η(t), λ = λ(t), α = α(t), with dη/dt < 0, dλ/dt < 0, dα/dt < 0 This leads to: - instability of long-term memory traces,- degradation of semantic consistency,- fragmentation of subjective time,- and non-uniform cognitive decline across structural layers. This work includes:- a minimal structural reinterpretation of Alzheimer’s disease,- a unified mathematical formulation,- a structural diagram linking IGS to neurocognitive breakdown,- and explicit testable predictions. This model does not replace biochemical explanations, but reinterprets them as underlying mechanisms of structural degradation. One-line definition:Alzheimer’s disease is a failure of structural information stabilization.
Koji Okino (Fri,) studied this question.