What question did this study set out to answer?

To investigate how advancing age influences the connection between cognitive impairment and brain volume in early multiple sclerosis.

April 12, 2026Annals of Clinical and Translational Neurology0 citationsOpen Access

View Full Paper

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

PAPiriyankan Ananthavarathan MPMarco Pitteri MFMichael Foster

Key Points

To investigate how advancing age influences the connection between cognitive impairment and brain volume in early multiple sclerosis.
Conducted longitudinal MRI assessments to measure gray matter volume (GMV).
Evaluated cognitive outcomes five years post first demyelinating event.
Analyzed the impact of aging on the association between GMV and cognitive outcomes.
Significant correlation found between GMV volumes and cognitive outcomes five years post-event.
Advancing age correlated with changes in GMV and cognitive outcomes.
Age modification suggests that older individuals may experience different cognitive impacts compared to younger ones.

Abstract

Five years after a first demyelinating event, GMV volumes on MRI are significantly associated with the presence of cognitive outcomes, while advancing age also appears to be associated with GMV and cognitive outcomes.

问 AI

Bookmark

View Full Paper

问 AI

Bookmark

View Full Paper

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Key Points

Abstract

Cite This Study

Also Consider

Also Consider