Design, synthesis, and anticancer evaluation of a novel imine-linked covalent organic framework correlated to molecular docking and DFT insights

Key Points

• The aim is to design and evaluate a new type of covalent organic framework for its anticancer properties.
• Synthesis of the novel imine-linked covalent organic framework
• Molecular docking studies to analyze interactions
• Density Functional Theory (DFT) assessments of stability and reactivity
• Anticancer activity tests against cancer cell lines
• The new framework demonstrates significant thermal stability
• Promising anticancer activity was observed in preliminary evaluations
• Molecular docking indicates strong interactions with targeted cancer pathways