STEMI triggers the mobilization of specific stem and progenitor cells into peripheral blood, a process in which stromal cell-derived factor-1 plays an important role.
The study demonstrates in the setting of STEMI a marked mobilization of mononuclear cells expressing specific cardiac, muscle, and endothelial markers as well as CD34/CXCR4+ and CD34/CD117+ and c-met+ stem cells and shows that stromal cell-derived factor-1 is an important factor influencing the mobilization.
Wojakowski et al. (2004) studied this question.