November 18, 2021Metabolism101 citationsOpen Access

Sodium/glucose cotransporter 2 (SGLT2) inhibitors improve cardiac function by reducing JunD expression in human diabetic hearts

RMRaffaele Marfella NDNunzia D’Onofrio MTMaria Consiglia Trotta

Structured PICO

Do SGLT2 inhibitors reduce JunD/PPAR-γ overexpression and lipid accumulation in human diabetic hearts?

Population

Heart transplant (HTX) recipients with diabetes

Intervention

SGLT2 inhibitors

Outcome

JunD/PPAR-γ overexpression and lipid accumulationsurrogate

SGLT2 inhibitors may improve cardiac function in diabetic cardiomyopathy by directly reducing JunD/PPAR-γ overexpression and lipid accumulation.

Abstract

Early pathogenesis in human diabetic cardiomyopathy is associated with JunD/PPAR-γ overexpression and lipid accumulation following HTX in recipients with diabetes. Remarkably, this phenomenon was reduced by concomitant therapy with SGLT2i, which acted directly on diabetic hearts.

问 AI

Bookmark

View Full Paper

Cite This Study

Marfella et al. (Thu,) studied this question.

synapsesocial.com/papers/69dbc63b50e1971baba3ca02 https://doi.org/https://doi.org/10.1016/j.metabol.2021.154936

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

问 AI

Bookmark

View Full Paper