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February 4, 2014Genome biology1,192 citationsOpen Access

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

AJAndrew E. JaffeRIRafael A. Irizarry

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Abstract

Our findings underscore the importance of considering cell composition variability in epigenetic studies based on whole blood and other heterogeneous tissue sources. We also provide software for estimating and exploring this composition confounding for the Illumina 450k microarray.

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Jaffe et al. (2014) studied this question.

synapsesocial.com/papers/69dbd29c7d378569a9836159https://doi.org/10.1186/gb-2014-15-2-r31
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