Can Lung 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) be used for the diagnosis and monitoring of Pulmonary Arterial Hypertension?
FDG-PET may serve as a sensitive imaging modality for diagnosing mild PAH and monitoring therapeutic vascular changes.
HIF-1α-mediated Glut1 up-regulation in proliferating vascular cells in PAH accounts for increased lung FDG-PET uptake. FDG-PET is sensitive to mild PAH and can monitor therapeutic changes in the vasculature.
Marsboom et al. (Fri,) studied this question.