Does discontinuing or not adhering to aspirin worsen prognosis in patients at risk for coronary artery disease?
Discontinuing aspirin in patients at moderate-to-high risk for CAD is associated with adverse prognostic implications and should only be done when bleeding risk clearly outweighs atherothrombotic risk.
Non-compliance or withdrawal of aspirin treatment has ominous prognostic implication in subjects with or at moderate-to-high risk for CAD. Aspirin discontinuation in such patients should be advocated only when bleeding risk clearly overwhelms that of atherothrombotic events.
Biondi‐Zoccai et al. (2006) studied this question.