Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway

Key Points

• The research aims to understand how chemerin influences pyroptosis and affects tumor progression in oral squamous cell carcinoma (OSCC).
• Investigated the role of chemerin in OSCC cells
• Analyzed the NLRP3/GSDMD-N pathway involvement
• Evaluated the prognostic significance of chemerin and pyroptosis levels in OSCC
• Chemerin facilitated pyroptosis in OSCC cells through the NLRP3/GSDMD-N pathway.
• Elevated levels of pyroptosis and chemerin were linked to poorer prognosis in OSCC.
• Pyroptosis promoted tumor progression via multiple pathways.