Introduction Feed behavior traits are directly linked to the sustainability of pig production. This study aimed to investigate the genetic basis of feeding behavior traits in Landrace and Yorkshire pigs, focusing on genomic regions, quantitative trait loci (QTL), candidate genes, and metabolic pathways associated with these traits. Methods Genome-wide association studies (GWAS) were performed, followed by functional enrichment analyses and integrative bioinformatics approaches to identify biologically relevant genomic regions, candidate genes, and pathways associated with feeding behavior traits. Results Several candidate genes and transcription factors were identified, including STAT3, STAT5A, STAT5B, RARA, SMAD4, MYC, FOXP3, SP1, NOTCH1, and RXRA. In addition, strong candidate genes such as SLC22A2, CPAMD8, and NKX2-6 were highlighted as potentially influencing feeding behavior traits. Discussion These findings improve the understanding of the genomic architecture underlying feeding behavior traits and provide valuable insights for the development of more efficient breeding programs, contributing to improved animal production efficiency and welfare.
Gervásio et al. (Thu,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: