Radial constraint of plastically compressed human dermo-epidermal skin substitutes mitigates in vitro contraction and enhances structural maturity

Key Points

• The aim is to evaluate how radial constraints affect the contraction and structural maturity of bioengineered skin substitutes.
• Developed a radial constraint design for skin substitutes
• Conducted in vitro experiments to assess contraction
• Analyzed the structural properties of bioengineered skin
• Radial constraints significantly reduced contraction in skin substitutes
• Enhanced structural maturity was observed in constrained samples
• The engineered solution shows potential for more reliable skin graft applications