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March 20, 2018BMC Biology75 citationsOpen Access

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

RBRaphaël BoursereauMAMichel Abou‐SamraSLSophie Lecompte

Key Points

Key points are not available for this paper at this time.

Abstract

The NLRP3 inflammasome plays a key pathogenic role in DMD and muscle inflammation, thereby opening new therapeutic perspectives for these and other related disorders.

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Boursereau et al. (2018) studied this question.

synapsesocial.com/papers/69dd5c7d7808b00a4799d014https://doi.org/10.1186/s12915-018-0501-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potential Therapeutic Action of Adiponectin in Duchenne Muscular Dystrophy2017 · 24 citations
  2. 2Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes2015 · 45 citations
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  4. 4Glucocorticoid Analogues: Potential Therapeutic Alternatives for Treating Inflammatory Muscle Diseases2012 · 18 citations
  5. 5The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response2014 · 809 citations