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March 20, 2018SHILAP Revista de lepidopterología74 citationsOpen Access

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

RBRaphaël BoursereauCentre National de la Recherche ScientifiqueMAMichel Abou‐SamraUCLouvainSLSophie LecompteUCLouvain

Key Points

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Abstract

The NLRP3 inflammasome plays a key pathogenic role in DMD and muscle inflammation, thereby opening new therapeutic perspectives for these and other related disorders.

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Boursereau et al. (2018) studied this question.

synapsesocial.com/papers/69dd5c7d7808b00a4799d014https://doi.org/10.1186/s12915-018-0501-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skeletal muscle secretome in Duchenne muscular dystrophy: a pivotal anti-inflammatory role of adiponectin2017 · 35 citations
  2. 2Muscular dystrophies: genes to pathogenesis2003 · 221 citations
  3. 3The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease2015 · 2,144 citations
  4. 4Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species2007 · 259 citations
  5. 5Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients2014 · 123 citations