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Hemolysis is a clinically significant scenario that requires continuous monitoring as oxygen carrying Red Blood Cells (RBC) in blood get damaged and release hemoglobin into plasma. Out of many, photoacoustics is a potential modality to detect presence of the hemoglobin in-vivo and in-vitro. So it is to examine here that how the hemolysis is reflected in photoacoustic response. With a low cost, low power photoacoustic system, it is found that, though total hemoglobin remains constant, photoacoustics with near infra-red (NIR) excitation can differentiate partially lysed samples from unlysed one by change in amplitude as well as rise time.
Banerjee et al. (Mon,) studied this question.