September 1, 2001Journal of Clinical Oncology122 citations
View Full PaperBody-Surface Area–Based Dosing Does Not Increase Accuracy of Predicting Cisplatin Exposure
Structured PICO
Does Body-Surface Area-based dosing of cisplatin improve the accuracy of predicting cisplatin exposure compared to fixed-dosing regimens?
P
Population
Patients receiving cisplatin
I
Intervention
Body-Surface Area-based dosing of cisplatin
C
Comparator
Fixed-dosing regimens
O
Outcome
Accuracy of predicting cisplatin exposure (CL(free))surrogate
BSA-based dosing of cisplatin does not increase the accuracy of predicting drug exposure, supporting a shift to fixed-dosing regimens.
Abstract
In view of the high interpatient variability in CL(free) relative to variation in observed BSA, no rationale for continuing BSA-based dosing was found. We recommend fixed-dosing regimens for cisplatin.