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历史-底物-生物化学和生理学。电子流的调节。促进从酸类生产到溶剂生产转变的因素。与溶剂生产阶段相关的事件（酶活性、ATP、生长、细胞分化等）。毒性。基因学和菌株改良。工艺发展。前景
Jones 等（周一）研究了这个问题。
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