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April 14, 2026Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity0 citationsOpen Access

The association between CALLY index and obesity in adolescents: a comparative analysis with traditional inflammatory markers

YLYanchao LiXSXiaoshan ShaoXYXiaoyan Yang

Key Result

Each 1-unit increase in the CALLY index was associated with a 3.20% reduction in the odds of obesity among adolescents (OR 0.968), significantly outperforming traditional inflammatory markers.

Key Points

  • This research aims to evaluate the effectiveness of the CALLY index as a predictor of obesity in adolescents compared to traditional inflammatory markers.
  • Comparative analysis of the CALLY index and traditional inflammatory markers.
  • Assessment of adolescents to determine obesity levels.
  • Integration of traditional covariates to enhance predictive accuracy.
  • The CALLY index outperformed traditional inflammatory markers in predicting adolescent obesity.
  • Incorporating traditional covariates improved the predictive accuracy of the CALLY index.

Study Design

Type

Cross-Sectional (n=2,188)

Structured PICO

Does the CALLY index predict obesity in adolescents better than traditional inflammatory markers?

P
Population
adolescents
I
Intervention
CALLY index
C
Comparator
traditional inflammatory markers
O
Outcome
obesitysurrogate

The CALLY index may serve as a valuable tool for early screening and intervention in adolescent obesity, offering better predictive accuracy than traditional inflammatory markers.

Main Result

Effect estimate: OR 0.968 (95% CI 0.958-0.977)

p-value: p=<0.001

Limitations

  • Cross-sectional design cannot establish a temporal relationship or infer causality.
  • Components of CALLY may be influenced by recent infections, trauma, or laboratory measurement errors.
  • Imputation model relies on the assumption of 'missing at random,' and unobserved confounding factors may still introduce bias.
  • Applicability of conclusions to other countries, ethnicities, or clinically high-risk populations requires external validation.
  • Does not assess the modifiability of CALLY as an intervention target.

Abstract

The CALLY index is a robust and independent predictor of obesity in adolescents, outperforming traditional inflammatory markers. Its integration with traditional covariates further enhances predictive accuracy, suggesting that the CALLY index could be a valuable tool for early screening and intervention in adolescent obesity.

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Cite This Study

Li et al. (2026) conducted a cross-sectional in Adolescent obesity (n=2,188). CALLY index vs. Traditional inflammatory markers (NLR, PLR, SII, SIRI) was evaluated on Obesity (BMI ≥ 95th percentile) (OR 0.968, 95% CI 0.958-0.977, p=<0.001). Each 1-unit increase in the CALLY index was associated with a 3.20% reduction in the odds of obesity among adolescents (OR 0.968), significantly outperforming traditional inflammatory markers.

synapsesocial.com/papers/69ddd8eee195c95cdefd6707https://doi.org/10.1007/s40519-026-01844-6
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