Does concomitant administration of ibuprofen, rofecoxib, acetaminophen, or diclofenac antagonize the irreversible platelet inhibition induced by aspirin?
Concomitant use of ibuprofen may limit the cardioprotective effects of aspirin by antagonizing its antiplatelet activity.
The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin. Treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin.
Catella-Lawson et al. (Thu,) studied this question.