Does standard prophylactic enoxaparin dosing lead to inadequate anti-Xa levels and increased DVT rates in critically ill trauma and surgical patients?
Standard prophylactic dosing of enoxaparin may be inadequate for surgical ICU patients, leading to low anti-Xa levels and increased DVT risk.
Standard dosing of enoxaparin leads to low anti-Xa levels in half of surgical ICU patients. Low levels are associated with a significant increase in the risk of DVT. These data support future studies using adjusted-dose enoxaparin.
Malinoski et al. (Thu,) studied this question.
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