April 15, 2026Diabetes Obesity and Metabolism0 citationsOpen Access
View Full PaperSemaGBA : A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight
Key Points
- The aim is to explore how semaglutide influences appetite and weight through metabolic and neural interactions.
- Developed a system dynamics model to simulate the gut-brain axis effects of semaglutide.
- Analyzed pathways involved in glucose regulation and appetite control.
- Conducted a validation to assess model effectiveness based on available data.
- Model illustrates how semaglutide affects appetite regulation and glucose metabolism.
- Findings suggest potential neural mechanisms that could be further investigated with more data.
Abstract
The SemaGBA model demonstrates how semaglutide achieves glucose control and weight loss through integrated metabolic and neural pathways. Validation is limited by data availability, but the framework provides hypotheses for future research into semaglutide's neural effects.