Integrated network toxicology and immune profiling identify ESR1 as a potential hub linking Benzoapyrene exposure to gastric cancer risk

Key Points

• The aim is to explore the link between Benzo[a]pyrene exposure and gastric cancer, focusing on ESR1 as a potential biomarker.
• Utilized integrated computational toxicology approaches.
• Conducted immune profiling to analyze immune features.
• Identified ESR1 as a pivotal connection between exposure and cancer risk.
• ESR1 was identified as a potential hub linking Benzo[a]pyrene exposure to gastric cancer risk.
• Both toxicological impact and immune features were shown to be influenced by ESR1.