This exploratory study demonstrates the potential and sensitivity of 7 T MP2RAGE T1 mapping for characterizing both focal and diffuse WM/GM SC tissue damage in MS. When combined with Z-score metrics, it provides a quantitative and individualized framework for assessing tissue integrity, grading the extent of microstructural impairment, and potentially monitoring neuroprotective treatment effects over time.
Laines-Medina et al. (Mon,) studied this question.