Spatial clustering of recently activated cytotoxic lymphocytes improve association with overall survival in women with high grade serous ovarian cancer | Synapse
April 16, 2026Cancer Epidemiology Biomarkers & Prevention1 citationsOpen Access
Spatial clustering of recently activated cytotoxic lymphocytes improve association with overall survival in women with high grade serous ovarian cancer
The research aims to explore how the spatial distribution of recently activated cytotoxic lymphocytes impacts survival predictions in ovarian cancer.
Validation of previous findings on CTL abundance and spatial contexture.
Survival analyses performed using models incorporating spatial data.
Focus on high grade serous ovarian cancer in women.
Incorporating spatial contexture with CTL counts improved model fit.
Positive association with overall survival observed when spatial data is included.
Abstract
This study validates our previous findings that adding spatial contexture to abundance, especially CTLs or recently activated CTLs, when performing survival analyses improves the fit of the models.