The research investigates how BDNF influences visceral hypersensitivity and anxiety linked to early-life stress through specific signaling pathways.
Examined BDNF's role in anxiety and hypersensitivity following early-life stress.
Analyzed the signaling mechanisms in the hippocampus, focusing on TrkB and CRF pathways.
Utilized experimental models to assess behavioral outcomes related to anxiety and sensitivity.
Findings indicate that BDNF significantly increases visceral hypersensitivity in response to early-life stress.
The interaction between hippocampal TrkB signaling and CRF is crucial in mediating these effects.
Results provide a potential target for treating stress-related irritable bowel syndrome (IBS).
Abstract
This study demonstrates that BDNF may mediate ELS-induced anxiety and visceral hypersensitivity through hippocampal TrkB-CRF signaling, providing a mechanistic basis for targeting BDNF in stress-related IBS.