Photoinduced amine-mediated hydrodifluoroalkylation of 3-methyleneisoindolin-1-ones

Key Points

• The aim is to develop a catalyst-free method for incorporating difluoroalkyl groups into heterocyclic compounds.
• Utilization of photoinduced reactions
• Amine-mediated processes
• Application on 3-methyleneisoindolin-1-ones
• Catalyst-free approach
• Successfully achieved hydrodifluoroalkylation without catalysts
• Effectively incorporated difluoroalkyl groups into molecular scaffolds
• Demonstrated the utility of this method in medicinal chemistry applications