What question did this study set out to answer?

The aim is to investigate how lenvatinib affects lipid metabolism and inhibits hepatocellular carcinoma (HCC) proliferation and metastasis.

April 16, 2026Hepatology Research0 citations

Lenvatinib Promotes Metabolic Reprogramming Through RTK to Inhibit Hepatocellular Carcinoma Proliferation and Metastasis

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XZXiaofang ZhaoJiamusi University SYShengxiang YanJiangsu Vocational College of Medicine JMJing MengTianjin University of Science and Technology

Key Points

The aim is to investigate how lenvatinib affects lipid metabolism and inhibits hepatocellular carcinoma (HCC) proliferation and metastasis.
Analyzed the effects of lenvatinib on HCC cells
Examined the role of the PDGF/GFR-MAPK-PLA2G4E axis
Explored potential for combination therapies focusing on metabolic pathways
Lenvatinib effectively inhibits HCC proliferation and metastasis
Regulated lipid metabolism through PDGF/GFR-MAPK-PLA2G4E pathway
Proposed new combination therapies targeting metabolic pathways for improved HCC treatment

Abstract

These findings establish that lenvatinib inhibits HCC by regulating lipid metabolism through the PDGF/GFR-MAPK-PLA2G4E axis, expanding the mechanistic understanding of RTK inhibitors and proposing metabolic pathway-targeted combination therapies for HCC.

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Lenvatinib Promotes Metabolic Reprogramming Through RTK to Inhibit Hepatocellular Carcinoma Proliferation and Metastasis

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Abstract

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