What question did this study set out to answer?

The research aims to investigate the relationship between systemic inflammation and serum neurofilament light chain levels in U.S. adults.

April 17, 2026Mediators of Inflammation1 citationsOpen Access

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The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross‐Sectional Study

JWJun WeiJilin Medical University YLYing LiuShenyang Pharmaceutical University JZJun ZhangHarbin Medical University

Key Points

The research aims to investigate the relationship between systemic inflammation and serum neurofilament light chain levels in U.S. adults.
Cross-sectional study design
Assessment of ln AISI values
Measurement of sNfL levels
Statistical analysis of associations between ln AISI and sNfL
Higher ln AISI values are linked to increased sNfL levels
A nonlinear relationship exists between ln AISI and sNfL
AISI may be an important marker beyond traditional clinical factors

Abstract

In the U.S. population, higher ln AISI values were independently associated with increased sNfL levels. A nonlinear relationship was observed between ln AISI and sNfL. This suggests that AISI may represent an important marker associated with sNfL levels beyond traditional clinical factors, and further studies are needed to better explore their association and potential underlying biological mechanisms.

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The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross‐Sectional Study

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Abstract

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