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This research evaluates the effectiveness of different myelin-sensitive metrics in assessing brain tissue integrity.

April 18, 2026American Journal of Neuroradiology0 citationsOpen Access

Comparative Evaluation of 3D-QALAS Myelin Volume Fraction, Inhomogeneous Magnetization Transfer, and Myelin Water Fraction

MNMoto Nakaya AHAkifumi HagiwaraJuntendo University YHYasunobu Hoshino

Key Points

This research evaluates the effectiveness of different myelin-sensitive metrics in assessing brain tissue integrity.
Utilized 3D-QALAS to measure myelin volume fraction in brain tissue.
Assessed inhomogeneous magnetization transfer ratio for comparison.
Analyzed normal-appearing white matter and lesion areas.
3D-QALAS-derived myelin volume fraction showed strong concordance with magnetization transfer ratio.
Greater deviation in lesion areas compared to normal-appearing white matter was observed.
Findings position 3D-QALAS as a viable biomarker for myelin integrity.

Abstract

3D-QALAS-derived myelin volume fraction demonstrated strong overall concordance with the inhomogeneous magnetization transfer ratio in normal-appearing brain tissue and greater lesion-associated deviation from normal-appearing white matter than the other myelin-sensitive metrics. These findings support 3D-QALAS-derived myelin volume fraction as a promising volumetric biomarker of myelin integrity with whole-brain coverage suitable for routine clinical application.

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Nakaya et al. (Wed,) studied this question.

synapsesocial.com/papers/69e31f7340886becb653ea9a https://doi.org/https://doi.org/10.3174/ajnr.a9351

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