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This study aims to compare imaging-based methods for assessing treatment response in neuroendocrine tumors following PRRT.

April 18, 2026Cancers0 citationsOpen Access

Comparing Response Evaluation Methods for PRRT in Neuroendocrine Tumors Insights

Comparing Response Evaluation Methods for PRRT in Neuroendocrine Tumors: Insights from an Exploratory Study

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Exploratory study compares imaging response assessment methods after PRRT in NET patients, suggesting implications for clinical outcomes.

This study aims to compare imaging-based methods for assessing treatment response in neuroendocrine tumors following PRRT.
Conducted a single-center retrospective analysis of NET patients treated with PRRT from 2020 to 2024.
Evaluated five imaging response criteria post-PRRT using [68Ga]Ga-DOTATOC PET/CT.
Performed nonparametric statistical analyses to correlate imaging findings with clinical outcomes.
Thirty-one patients were evaluated post-PRRT, showing varied response rates across different imaging methods.
Functional imaging methods had higher response rates (MORE 66%, Visual PET 68%, ZP 70%) compared to RECIST (40%) and Krenning score (21%).
After a median follow-up of 37 months, 58% of patients experienced disease progression with no significant association between imaging responses and progression-free survival.

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Guglielmo et al. (2026) studied this question.

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April 18, 2026Cancers0 citationsOpen Access

Comparing Response Evaluation Methods for PRRT in Neuroendocrine Tumors: Insights from an Exploratory Study

Authors

Exploratory study compares imaging response assessment methods after PRRT in NET patients, suggesting implications for clinical outcomes.

This study aims to compare imaging-based methods for assessing treatment response in neuroendocrine tumors following PRRT.
Conducted a single-center retrospective analysis of NET patients treated with PRRT from 2020 to 2024.
Evaluated five imaging response criteria post-PRRT using [68Ga]Ga-DOTATOC PET/CT.
Performed nonparametric statistical analyses to correlate imaging findings with clinical outcomes.
Thirty-one patients were evaluated post-PRRT, showing varied response rates across different imaging methods.
Functional imaging methods had higher response rates (MORE 66%, Visual PET 68%, ZP 70%) compared to RECIST (40%) and Krenning score (21%).
After a median follow-up of 37 months, 58% of patients experienced disease progression with no significant association between imaging responses and progression-free survival.

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Guglielmo et al. (2026) studied this question.

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