April 19, 2026Trends in Genetics0 citationsOpen Access
View Full PaperThe gut microbiome as an effector of metabolic disease gene variants
Key Points
- This study examines the relationship between the gut microbiome and genetic factors related to metabolic diseases.
- Reviewed existing literature on genetic drivers of the gut microbiome and metabolic disease.
- Analyzed studies linking gene variants to microbiome alterations and metabolic functions.
- Identified overlaps between genetic drivers of gut microbiome and metabolic disease.
- Suggests that genes influencing metabolism may do so by altering the gut microbiome.
Abstract
Here, we discuss emerging studies that have identified overlap in the genetic drivers of the gut microbiome and metabolic disease, and we evaluate the possibility that some genes affecting host metabolic function do so by first manipulating the microbiome.