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April 19, 2026Osteoporosis International0 citationsOpen Access

Vertebral fractures and muscle function in glucocorticoid-treated individuals with Duchenne muscular dystrophy: a cohort study

ACAnna CapassoCAChiara ArpaiaCPChiara Panicucci

Key Points

  • To assess the relationship between muscle function and vertebral fractures in individuals with Duchenne muscular dystrophy receiving glucocorticoid treatment.
  • Cohort study design
  • Assessment of ambulatory status and functional scores
  • Evaluation of risk factors including glucocorticoid initiation and BMD Z-scores
  • Ambulatory status and functional scores were not reliable predictors of vertebral fractures.
  • There was a confirmed association between early glucocorticoid therapy initiation and low BMD Z-scores.
  • The findings suggest a need for enhanced surveillance for vertebral fractures from glucocorticoid initiation.

Abstract

Our results suggest that ambulatory status and functional scores alone may not be reliable predictors for developing VFs and confirm the association with known risk factors, such as early initiation of glucocorticoid therapy and low BMD Z-scores, highlighting the need to guarantee a careful surveillance of possible VFs from the time of glucocorticoid initiation.

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Cite This Study

Capasso et al. (2026) studied this question.

synapsesocial.com/papers/69e47193010ef96374d8ddefhttps://doi.org/10.1007/s00198-026-07990-y
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