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April 19, 2026Analytical Cellular Pathology0 citationsOpen Access

The m6A Reader YTHDF3 Promotes Glioma Progression by Regulating the m6A Modification of lncRNA‐PAR5

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LXLiufei XuYXYuan XuYDYongBin Duan

Key Points

  • To investigate how YTHDF3 influences glioma progression through its interaction with lncRNA-PAR5.
  • Examined the effects of YTHDF3 on glioma cell proliferation, invasion, and migration.
  • Analyzed the m6A modification levels of lncRNA-PAR5 to assess YTHDF3's regulatory role.”
  • Utilized cell culture experiments to simulate glioma progression.
  • YTHDF3 enhances m6A modifications on lncRNA-PAR5, leading to decreased PAR5 expression.
  • Increased YTHDF3 levels correlate with enhanced glioma cell proliferation, invasion, and migration.
  • The YTHDF3/PAR5 axis serves as a critical mechanism in glioma progression.

Abstract

YTHDF3 promotes glioma cell proliferation, invasion, and migration by inhibiting PAR5 expression through enhancing its m6A modification. This study reveals the critical role of the YTHDF3/PAR5 axis in glioma progression and provides a potential novel target for glioma‑targeted therapy.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69e473bd010ef96374d8f869https://doi.org/10.1155/ancp/8467384
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