What question did this study set out to answer?

To investigate how YTHDF3 influences glioma progression through its interaction with lncRNA-PAR5.

April 19, 2026Analytical Cellular Pathology0 citationsOpen Access

The m6A Reader YTHDF3 Promotes Glioma Progression by Regulating the m6A Modification of lncRNA‐PAR5

LXLiufei XuSun Yat-sen University YXYuan XuKunming Medical University YDYongBin DuanKunming Medical University

Key Points

To investigate how YTHDF3 influences glioma progression through its interaction with lncRNA-PAR5.
Examined the effects of YTHDF3 on glioma cell proliferation, invasion, and migration.
Analyzed the m6A modification levels of lncRNA-PAR5 to assess YTHDF3's regulatory role.”
Utilized cell culture experiments to simulate glioma progression.
YTHDF3 enhances m6A modifications on lncRNA-PAR5, leading to decreased PAR5 expression.
Increased YTHDF3 levels correlate with enhanced glioma cell proliferation, invasion, and migration.
The YTHDF3/PAR5 axis serves as a critical mechanism in glioma progression.

Abstract

YTHDF3 promotes glioma cell proliferation, invasion, and migration by inhibiting PAR5 expression through enhancing its m6A modification. This study reveals the critical role of the YTHDF3/PAR5 axis in glioma progression and provides a potential novel target for glioma‑targeted therapy.

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