Tuning the hydrophobicity of glycine ester through N -acylation and introducing quaternary pyridinium groups enable the selectivity against Gram-positive bacteria

Key Points

• To explore how tuning glycine ester affects its hydrophobicity and selectivity towards Gram-positive bacteria.
• Utilized N-acylation to modify glycine ester structure
• Introduced quaternary pyridinium groups
• Assessed effects on bacterial membrane integrity
• QPyNAGe showed enhanced selectivity against Gram-positive bacteria
• Demonstrated impact on bacterial membrane integrity