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April 20, 2026New England Journal of Medicine12 citations

High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure

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JFJean-Pierre FratJQJ. QuenotCGChristophe Guitton

Key Points

  • To evaluate the effect of high-flow nasal cannula oxygen delivery on mortality in patients with acute hypoxemic respiratory failure.
  • Randomized trial
  • Included patients with acute hypoxemic respiratory failure
  • Evaluated mortality at day 28
  • High-flow nasal cannula did not significantly reduce mortality at day 28 compared to standard oxygen delivery (exact rates not provided)

Abstract

Among patients with acute hypoxemic respiratory failure, the use of oxygen delivered through a high-flow nasal cannula did not significantly reduce mortality at day 28. (Funded by the French Ministry of Health and Fisher and Paykel Healthcare; SOHO ClinicalTrials.gov number, NCT04468126.).

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Cite This Study

Frat et al. (2026) studied this question.

synapsesocial.com/papers/69e598e585ab6d890cfade62https://doi.org/10.1056/nejmoa2516087
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