Development of novel targeted therapies to overcome cetuximab resistance in oral cancer

Key Points

• The research aims to identify effective targeted therapies that can overcome resistance to cetuximab in oral cancer.
• Developed novel drug candidates based on molecular pathways.
• Conducted in vitro studies to test drug efficacy on cancer cell lines.
• Analyzed resistance mechanisms through genetic profiling.
• Identified key molecular pathways influencing cetuximab resistance.
• Demonstrated enhanced efficacy of novel therapies in resistant oral cancer models.
• Showed improved patient outcomes with targeted therapies compared to cetuximab alone.