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April 22, 2026Stem Cell Research0 citationsOpen Access

Generation of a human induced pluripotent stem cell line SDQLCHi087-A from a healthy Chinese child donor

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ZLZiming LinALAnna LiHZHaitao Zhang

Key Points

  • The aim is to generate a human induced pluripotent stem cell (iPSC) line for use in disease studies.
  • Reprogramming of peripheral blood mononuclear cells from a healthy child donor.
  • Utilization of integration-free episomal plasmids for reprogramming.
  • Assessment of karyotype and pluripotency markers after cell line generation.
  • The iPSC line SDQLCHi087-A exhibited a normal karyotype.
  • High expression levels of pluripotent markers were confirmed.
  • The line demonstrated the ability to differentiate into three germ layers in vitro.

Abstract

In this study, a healthy iPSC line SDQLCHi087-A was successfully generated by reprogramming from peripheral blood mononuclear cells using integration-free episomal plasmids. The iPSC line presented a normal karyotype, expressed high levels of pluripotent markers, and exhibited the ability to differentiate to three germ layers in vitro. The cell line serves as a valuable control for studies of molecular pathogenesis and the development of disease models.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69e8656e6e0dea528dde9eb1https://doi.org/10.1016/j.scr.2026.103997
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