USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐ mRNA splicing

Key Points

• To investigate how USB1 influences neutrophil maturation and myeloid progenitor differentiation through RNA regulation.
• In vivo experiments to assess neutrophil maturation
• Analysis of miRNA and mRNA expression levels
• USB1 deficiency leads to disrupted neutrophil maturation
• Altered expression of specific miRNAs and mRNAs is observed