What question did this study set out to answer?

To evaluate metabolic changes in the reticuloendothelial system following CAR-T therapy using PET/CT imaging.

April 22, 20260 citations

Metabolic changes in reticuloendothelial system following Tisagenlecleucel chimeric antigen receptor T cell (CAR-T) therapy using 18F-FDG PET/CT.

SSShashi B. SinghHospital of the University of Pennsylvania OGOm H. GandhiHospital of the University of Pennsylvania CHCameron Haghshenas

Key Points

To evaluate metabolic changes in the reticuloendothelial system following CAR-T therapy using PET/CT imaging.
Utilized fluorine-18-FDG PET/CT to assess metabolic activity in various organs post-therapy.
Compared metabolic changes in lymphoma adenopathy, bone marrow, spleen, and liver.
Significant decrease in metabolic activity in lymphoma adenopathy, bone marrow, and spleen observed.
No statistically significant changes detected in the liver.

Abstract

Fluorine-18-FDG PET/CT demonstrated a decrease in metabolic activity of lymphoma adenopathy, bone marrow, and spleen, after tisagenlecleucel therapy. However, changes in the liver were not statistically significant. These findings suggest that Tisagenlecleucel chimeric antigen receptor T cell (CAR-T) therapy induces a broad systemic metabolic response within the reticuloendothelial system.

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