This research aims to evaluate the effectiveness of hdx-ms epitope characterization for assessing antibodies in vaccine potency testing.
Conducted in vitro tests using hdx-ms to analyze antibody interactions with vaccine epitopes.
Developed protocols for sandwich ELISA as a replacement for traditional potency tests.
Identified key epitopes that correlate with antibody potency.
Demonstrated that hdx-ms can effectively differentiate suitable antibodies for ELISA-based assays.
Abstract
Many current vaccine potency test methods relying on animal testing methods are aimed to be replaced by alternative methods, as per the 3Rs initiative. In vitro potency testing by sandwich...
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HDX-MS Epitope Characterization for Evaluating Antibody Suitability for ELISA-based In Vitro Potency Testing of Vaccines | Synapse