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April 23, 2026Cell Reports0 citationsOpen Access

Durable control of autoimmunity requires sustained stimulation of regulatory T cells

JPJanika PõderAYAixin YuYDYing Ding

Key Points

  • The research aims to understand how long-term stimulation of regulatory T cells can lead to durable control of autoimmunity.
  • Administered mIL-2/CD25 to NOD mice
  • Monitored Treg population, ILC2, and NK cell levels
  • Assessed the clonal expansion of autoreactive T cells
  • Sustained increases in Tregs were linked to full control of T1D in NOD mice
  • Expansion of ILC2 and NK cells accompanied Treg increases
  • Reduced clonal expansion of autoreactive T cells observed alongside Treg persistence.

Abstract

Highlights mIL-2/CD25 is administered to cause persistent or oscillating increases in Tregs T1D in NOD mice is fully controlled only when Treg increases persist long-term mIL-2/CD25 expands Tregs, ILC2, and NK cells; the latter two also express regulatory properties Efficacy is accompanied by a reduction in the clonal expansion of autoreactive T cells

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Cite This Study

Põder et al. (2026) studied this question.

synapsesocial.com/papers/69e9b6aa85696592c86eb0b8https://doi.org/10.1016/j.celrep.2026.117292
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