What question did this study set out to answer?

The research aims to understand how long-term stimulation of regulatory T cells can lead to durable control of autoimmunity.

April 23, 2026Cell Reports0 citationsOpen Access

Durable control of autoimmunity requires sustained stimulation of regulatory T cells

JPJanika Põder AYAixin Yu YDYing Ding

Key Points

The research aims to understand how long-term stimulation of regulatory T cells can lead to durable control of autoimmunity.
Administered mIL-2/CD25 to NOD mice
Monitored Treg population, ILC2, and NK cell levels
Assessed the clonal expansion of autoreactive T cells
Sustained increases in Tregs were linked to full control of T1D in NOD mice
Expansion of ILC2 and NK cells accompanied Treg increases
Reduced clonal expansion of autoreactive T cells observed alongside Treg persistence.

Abstract

Highlights mIL-2/CD25 is administered to cause persistent or oscillating increases in Tregs T1D in NOD mice is fully controlled only when Treg increases persist long-term mIL-2/CD25 expands Tregs, ILC2, and NK cells; the latter two also express regulatory properties Efficacy is accompanied by a reduction in the clonal expansion of autoreactive T cells

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Cite This Study

Põder et al. (2026) studied this question.

synapsesocial.com/papers/69e9b6aa85696592c86eb0b8 https://doi.org/10.1016/j.celrep.2026.117292

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April 23, 2026Cell Reports0 citationsOpen Access

Durable control of autoimmunity requires sustained stimulation of regulatory T cells

JPJanika Põder AYAixin Yu YDYing Ding

Key Points

The research aims to understand how long-term stimulation of regulatory T cells can lead to durable control of autoimmunity.
Administered mIL-2/CD25 to NOD mice
Monitored Treg population, ILC2, and NK cell levels
Assessed the clonal expansion of autoreactive T cells
Sustained increases in Tregs were linked to full control of T1D in NOD mice
Expansion of ILC2 and NK cells accompanied Treg increases
Reduced clonal expansion of autoreactive T cells observed alongside Treg persistence.

Abstract

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Cite This Study

Põder et al. (2026) studied this question.

synapsesocial.com/papers/69e9b6aa85696592c86eb0b8 https://doi.org/10.1016/j.celrep.2026.117292

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